28 – 29 JANUARY 2017 r.

When Walter Bradford Cannon first coined the term homeostasis in 1914, he sought to emphasise the importance of maintaining a balance between the body and its environment when the body is under attack.
In 1988, Sterling and Eyer introduced the idea of allostasis in reference to the body’s ability to maintain equilibrium by making adjustments in response to daily stressors. In other words, allostasis means changing to maintain stability. However, prolonged or irregular allostasis leads to „allostatic overload”. McEwen invented this term in reference to anomalies and prolonged neuroendocrine, metabolic, and immune system responses that result in chronic pathologies. This is the price for adapting to the many psycho-social and environmental challenges the body faces. Reducing allostatic load, which is the goal of this symposium, means limiting chronic disease. A wide range of multi-dimensional prevention strategies and a holistic approach to the individual are key to avoiding allostatic overload.

Gérard Ostermann
Sterling, P.; Eyer, J. (1988). „Allostasis: A new paradigm to explain arousal pathology”. In Fisher, S.;
Reason, J. T. Handbook of life stress, cognition, and health. Chichester, NY: Wiley.



1st day – Saturday 28 January 2017 – MORNING

9 am: Opening session Dr Christian Leclerc & Professor Gérard Ostermann

9.30 am: Homeostasis – Allostasis: definition of these concepts and their place in preventive medicine
Professor Maurice Dematteis – Professor of Addictology & Pharmacology, Interregional Coordinator of DESC of Addictology, Grenoble teaching hospital

10.15 am: Bone and joint pain: from physiopathology to practice
Professor Serge Perrot – Head of the centre for pain studies and treatment (CETD) of the Hôtel Dieu hospital group, University Professor, University Paris Descartes.

11 am: Break

11.30 am: Microbiota-Gut-Brain axis: influence on normal homeostasis and contribution to risk of pathology
Professor Bruno Bonaz – Gastroenterologist and neuro-physiologist in the Hepato-
Gastroenterology department of the Grenoble teaching hospital, Director of the ‚Stress and neuro-digestive interactions’ team, Institut des Neurosciences.

12.15 pm: Microbiota, immunological tolerance and allergy
Dr Cyrille Hoarau – University-hospital teacher, senior university lecturer – hospital practitioner – Immunology, immuno-allergist doctor at Tours CHRU teaching hospital.

1st day – Saturday 28 January 2017 – AFTERNOON

1 pm: Lunch

2.30 pm: The alliance, a cure for non-observance
Professor André Grimaldi – acknowledged diabetology expert, former head of department at Pitié-Salpêtrière, emeritus professor of endocrinology at Pitié-Salpêtrière, founder of the movement to defend public hospitals.

3.15 pm: Metabolic consequences of lack of sleep
Karine Spiegel, PhD – Neurosciences Research Centre of Lyon – ‚Integrated physiology of the waking system’.

4 pm: Break

4.30 pm: Intestinal microbiome, a factor for successful immunotherapy in clinical oncology
Professor Guy Gorochov – Professor of Immunology, Director of the research team at the Centre for Immunology and Infectious Diseases at Pitié-Salpêtrière.

5.15 pm: Bacteria and man: prospects for treatment with host-friendly bacteria
Professor Gabriel Perlemuter – University professor, hospital practitioner (PU-PH), head of hepato-gastroenterology and nutrition department – Antoine-Béclère Hospital.

6 pm: Closing session

2nd day – Sunday 29 January 2017

8.45 am: Welcome

Special diets and Irritable Bowel Syndrome
Professor Jean-Marc Sabaté

A multi-layered approach to depression: the solutions in health medicine
Dr Patrick Lemoine – Dr Marc Beck

A new diagnostic tool to assist patients in connection with a health medicine exam
Professor Eric Bertin – Dr Jean-Philippe Astruc – Loïc Lenoir PhD

Invitation on a voyage: discover narrative therapy
Professor Gérard Ostermann – Professor Gérard Ribes

New perspectives: herbal medicine support for the immune system in its development
Dr Martine Charles

12.30 pm: Closing buffet and drinks